Combined RSS Items
- J. Anal. At. Spectrom., 2025, Advance ArticleDOI: 10.1039/D4JA00409D, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yanbei Zhu, Guosheng Yang, Aya Sakaguchi, Tsutomu Miura, Yasuyuki Shikamori, Jian ZhengThis review covers advances and applications of ICP-QMS/QMS in the analysis of rare earth elements and radionuclides. Specifical attention was paid to the strategies for separating spectral interferences.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00056
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00477
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00478
- ABSTRACT The identification of species is a crucial component of the Chinese patent medicine (CPM) quality evaluation system. Nevertheless, the intricate and varied chemical compositions of different herbs pose a persistent challenge to this study. This study proposes a strategy combining high-resolution mass spectrometry with molecular networking (MN) data processing tools to comprehensively characterize the compounds in Yixishu lotion (YXSL) and identify the species composition. First, the data collected by HPLC-Q-TOF-MS were comprehensively and systematically visualized and analyzed using MN. […]
- ABSTRACT A rapid and sensitive ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) method for the determination of bisoprolol in human plasma was established and validated. The sample was pretreated by methanol precipitation protein, and the isotope bisoprolol-d5 was used as the internal standard. The chromatographic column was ACQUITY UPLC BEH-C18 column (2.1 × 50 mm, 1.7 μm), with methanol and 0.2% formic acid aqueous solution as mobile phase for gradient elution. The electrospray ionization (ESI) source was used in the positive ion mode, and […]
- Analytical ChemistryDOI: 10.1021/acs.analchem.4c06345
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c00166
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c00157
- European Journal of Mass Spectrometry, Ahead of Print. This article describes the key achievements over the past 10 years in the microsecond pulsed glow discharge mass spectrometry applied to the analysis of solids and gaseous mixtures. The solid-state analysis allows studying solid materials with different …
- J. Anal. At. Spectrom., 2025, Accepted ManuscriptDOI: 10.1039/D5JA00028A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christopher D. Standish, J. Andy Milton, Rachel M. Brown, Gavin L. FosterThe accuracy of boron isotope analysis by laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS), particularly when the mass bias correction utilises non-matrix-matched reference materials, is compromised by matrix-…The content of this RSS Feed (c) The Royal Society of Chemistry
-  Time flies when you're a new institute! Parallel Squared is about to turn 2 and they decided to have a Research Festival! Check this out. Yes I want to plexDIA, but my mTRAQ kits only let me do 3 channels. With tagging and pooling that's a lot of work for only 3x throughput. 9-plex?? That's almost as much as I can TMT on my TIMSTOF!! You can attend in person if you register soon (and there is still space) and remote attendance is an […]
-  MALDI mass spectrometry is beautiful and can have really impressive spatial resolution these days, but a single spectrum can only look at so many things at once. Even if you had an amazing ion capacity and dynamic range, once you divide that by thousands of tryptic peptides (and matrix) ions that are around you're not going to see much past the absolute highest intensity stuff. I think the very best we ever saw from a single MALDI shot in Namandje's lab […]
- The main genetic risk factor for Alzheimers disease (AD) is the presence of the apolipoprotein E4 (APOE4) allele. While APOE4 increases the risk of developing AD, the APOE2 allele is protective and APOE3 is risk-neutral. In the brain, APOE is primarily expressed by astrocytes and plays a key role in various processes including cholesterol and lipid transport, neuronal growth, synaptic plasticity, immune response and energy metabolism. Disruptions in brain energy metabolism are considered a major contributor to AD pathophysiology, raising […]
- IntroductionIn preclinical Alzheimers disease (AD), oxidative stress induces non-enzymatic protein damage–detected as cerebrospinal fluid (CSF) biomarkers–and disrupts sleep-related networks, altering sleep electroencephalographic patterns. Due to the invasiveness of CSF sampling, quantitative electroencephalography (qEEG) is proposed as a non-invasive alternative for predicting oxidatively modified protein levels via Machine Learning (ML). MethodsForty-two mild-to-moderate AD patients underwent polysomnography (PSG). qEEG features were extracted. CSF protein oxidation markers levels –glutamic semialdehyde, aminoadipic semialdehyde, N{varepsilon}-carboxyethyl-lysine, N{varepsilon}-carboxymethyl-lysine, and N{varepsilon}-malondialdehyde-lysine –were assessed by gas chromatography/mass spectrometry, and […]
- Data-independent acquisition (DIA) and data-dependent acquisition (DDA) are frequently employed in the execution of tandem mass spectrometry (MS2) analyses. This study explored the application of DIA (MSe) and DDA (fast-DDA) in liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics using Panax genus samples. MSe provided comprehensive sample information, extracting more ion peaks with better peak shape and increased scan points compared to fast-DDA. Features from MSe data are four times more than those from fast-DDA data. Fast-DDA, however, delivered high-quality MS2 data, […]
- Publication date: Available online 1 April 2025Source: Journal of ProteomicsAuthor(s): Dandan Zhang, Hairong Zhang, Yuexin Yang, Ying Jin, Yingjie Chen, Caisheng Wu
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00465
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00012
- Publication date: Available online 1 April 2025Source: International Journal of Mass SpectrometryAuthor(s): Sudam S. Mane, Easton K. Cox, Cole D. Warner, David V. Dearden, Kenneth W. Lee
- Analytical ChemistryDOI: 10.1021/acs.analchem.4c05228
- Publication date: Available online 1 April 2025Source: Analytica Chimica ActaAuthor(s): Guoliang Huang, Baoshan Zang, Yunna Li, Guohua Zhu, Kezhi Jiang
- Publication date: Available online 1 April 2025Source: Analytica Chimica ActaAuthor(s): Jianglong Du, Shutong Yang, Yanqiu Chu, Yinghua Yan, Zhenhua Li, Chuan-Fan Ding
- Publication date: Available online 1 April 2025Source: Analytica Chimica ActaAuthor(s): Gaosheng Zhao, Yuliang Huang, Bin Jia, Jiafan Ji, Ping Cheng
- Â This is a solid new resource for figuring out if your search engine is lying to you about those modified peptides. Case study? That miserable region of histones where everything is conserved and everything can have multiple PTMs and – worst of all -people really truly care about which PTM is where!Â